Scientific publications

Last 25 articles SCOPUS

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  • Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes; Nature Communications; December 2024; DOI: 10.1038/s41467-024-47020-1
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  • Unraveling sex differences in Parkinson's disease through explainable machine learning; Journal of the Neurological Sciences; 15 July 2024; DOI: 10.1016/j.jns.2024.123091
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  • -PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis; Pain; 1 May 2024; DOI: 10.1097/j.pain.0000000000003114
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  • The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPI–Dynamic Contrast-Enhanced challenge; Magnetic Resonance in Medicine; May 2024; DOI: 10.1002/mrm.29909
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  • Stochastic brain dynamics exhibits differential regional distribution and maturation-related changes; NeuroImage; 15 April 2024; DOI: 10.1016/j.neuroimage.2024.120562
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  • Beyond multilayer perceptrons: Investigating complex topologies in neural networks; Neural Networks; March 2024; DOI: 10.1016/j.neunet.2023.12.012
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  • 4Ward: A relayering strategy for efficient training of arbitrarily complex directed acyclic graphs; Neurocomputing; 1 February 2024; DOI: 10.1016/j.neucom.2023.127058
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  • The EXPERIENCE Project: Automatic virtualization of 'extended personal reality' through biomedical signal processing and explainable artificial intelligence [Applications Corner]; IEEE Signal Processing Magazine; 1 January 2024; DOI: 10.1109/MSP.2023.3344430
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  • Enabling uncertainty estimation in neural networks through weight perturbation for improved Alzheimer's disease classification; Frontiers in Neuroinformatics; 2024; DOI: 10.3389/fninf.2024.1346723
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  • Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry; Social Cognitive and Affective Neuroscience; 2024; DOI: 10.1093/scan/nsae006
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  • A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis; eLife; 2024; DOI: 10.7554/eLife.79169
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  • Neuroanatomical markers of familial risk in adolescents with conduct disorder and their unaffected relatives; Psychological Medicine; 5 April 2023; DOI: 10.1017/S0033291721003202
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  • The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots; Cellular and Molecular Life Sciences; April 2023; DOI: 10.1007/s00018-023-04744-5
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Scientific publications

Last 50 articles PubMed

  • Advancing optoelectronic characteristics of Diketopyrrolopyrrole-Based molecules as donors for organic and as hole transporting materials for perovskite solar cells
    on 21 June 2024

    A stable and efficient hole-transport material (HTM) is crucial for high-performance perovskite solar cells (PSCs). A 2,2',7,7'-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene (Spiro-MeOTAD) being used widely to prepare highly efficient PSCs. However, Spiro-MeOTAD has some limitations due to its complex synthesis, which increases its cost, and it also requires dopants to improve its performance. Therefore, we designed thirteen unique small-molecule-based HTMs (MK1-MK13), which are...

  • Decoding visual brain representations from electroencephalography through knowledge distillation and latent diffusion models
    on 20 June 2024

    Decoding visual representations from human brain activity has emerged as a thriving research domain, particularly in the context of brain-computer interfaces. Our study presents an innovative method that employs knowledge distillation to train an EEG classifier and reconstruct images from the ImageNet and THINGS-EEG 2 datasets using only electroencephalography (EEG) data from participants who have viewed the images themselves (i.e. "brain decoding"). We analyzed EEG recordings from 6...

  • The Mediterranean Diet in Pregnancy: Implications for Maternal Brain Morphometry in a Secondary Analysis of the IMPACT BCN Randomized Clinical Trial
    on 19 June 2024

    CONCLUSIONS: The promotion of a Mediterranean diet during pregnancy has a significant effect on maternal brain structure.

  • Retrieving and reconstructing conceptually similar images from fMRI with latent diffusion models and a neuro-inspired brain decoding model
    on 17 June 2024

    Brain decoding is a field of computational neuroscience that aims to infer mental states or internal representations of perceptual inputs from measurable brain activity. In this study, we propose a novel approach to brain decoding that relies on semantic and contextual similarity. We use several fMRI datasets of natural images as stimuli and create a deep learning decoding pipeline inspired by the bottom-up and top-down processes in human vision. Our pipeline includes a linear...

  • Salicylic acid-mediated alleviation of salt stress: Insights from physiological and transcriptomic analysis in Asarum sieboldii Miq
    on 14 June 2024

    As global agriculture faces the pressing threat of salt stress, innovative solutions are imperative for sustainable agriculture. The remarkable potential of salicylic acid (SA) in enhancing plant resilience against environmental stressors has recently gained attention. However, the specific molecular mechanisms by which SA mitigates salt stress in Asarum sieboldii Miq., a valuable medicinal plant, remain poorly understood. Here, we evaluated the physiological and transcriptomic regulatory...

  • Precision agriculture for wine production: A machine learning approach to link weather conditions and wine quality
    on 13 June 2024

    The agricultural sector, in particular viticulture, is highly susceptible to variations in the environment, crop conditions, and operational factors. Effectively managing these variables in the field necessitates observation, measurement, and responsive actions. Leveraging new technologies within the realm of precision agriculture, vineyards can enhance their long-term efficiency, productivity, and profitability. In our work we propose a novel analysis of the impact of pedoclimatic factors on...

  • Unraveling sex differences in Parkinson's disease through explainable machine learning
    on 13 June 2024

    Sex differences affect Parkinson's disease (PD) development and manifestation. Yet, current PD identification and treatments underuse these distinctions. Sex-focused PD literature often prioritizes prevalence rates over feature importance analysis. However, underlying aspects could make a feature significant for predicting PD, despite its score. Interactions between features require consideration, as do distinctions between scoring disparities and actual feature importance. For instance, a...

  • Management of iron deficiency anemia during pregnancy: a midwife-led continuity of care model
    on 10 June 2024

    CONCLUSION: Our midwife-led model of care demonstrated an improvement in iron levels among pregnant women. The model addressed the challenges of anemia prevalence in Pakistan and underscored the significance of empowering front-line healthcare providers, such as community midwives (CMWs) for managing these common conditions.

  • GLSTM: On Using LSTM for Glucose Level Prediction
    on 24 May 2024

    The Prediabetes impacts one in every three individuals, with a 10% annual probability of transitioning to type 2 diabetes without lifestyle changes or medical interventions. It's crucial to manage glycemic health to deter the progression to type 2 diabetes. In the United States, 13% of individuals (18 years of age and older) have diabetes, while 34.5% meet the criteria for prediabetes. Diabetes mellitus and prediabetes are more common in older persons. Currently, nevertheless, there aren't many...

  • Transformation of heavy metals from contaminated water to soil, fodder and animals
    on 22 May 2024

    A serious environmental problem that threatens soil quality, agricultural productivity, and food safety is heavy metal pollution in water sources. Heavy metal pollution is the main problem in tehsil Pasrur, Sialkot, Pakistan. Present study was arranged to notice the heavy metals in water, soil, forages and buffalo milk. There are seven sites that were used for this experiment. Highest malondialdehyde (MDA) contents (3.00 ± 0.01) were noticed in barseem roots at site 7. Ascorbate Peroxidase (APX)...

  • Visible light assisted photooxidative facile degradation of azo dyes in water using a green method
    on 21 May 2024

    In this study, the methyl orange (MO) dye has been degraded after screening several azo dyes due to its effective results and being toxic and carcinogenic to aquatic life and humans. An environmentally friendly, economical, and green method for water purification was used in this study using the photooxidative method. Several organic acids were screened for oxidative applications against various azo dyes but due to better results, methyl orange was selected for the whole study. Ascorbic acid,...

  • 2D Janus ZrSSe/SnSSe Heterostructure: A Promising Candidate for Photocatalytic Water Splitting
    on 13 May 2024

    The distinctive physical characteristics and wide range of potential applications in optoelectronic and photovoltaic devices have ignited significant interest in two-dimensional materials. Intensive research attention has been focused on Janus transition metal dichalcogenides due to their unique properties resulting from symmetry disruption and their potential in photocatalysis applications. Motivated by the current fascination with Janus TMD heterostructures, we conducted first-principles...

  • Serological and epidemiological investigation of Mycobacterium avium subspecies paratuberculosis in bovines in Pakistan
    on 26 April 2024

    CONCLUSION: This study concluded that tuberculin testing can be used in conjunction with ELISA to screen animals for paratuberculosis in countries with scarce resources, such as Pakistan. The efficacy of disease diagnosis can be improved by combining multiple tests.

  • Exploring the Concordance Between High-Risk Human Papillomavirus Infections in Cervical and Oral Sites Among Females: A Cross-Sectional Study in Punjab, Pakistan
    on 25 April 2024

    CONCLUSION: This study suggests that HR-HPV cervical infections may increase the risk of oral transmission, especially during orogenital sexual practices. Thus, it is important to recognize that HPV infections may be linked in both areas. We emphasize the importance of comprehensive cervical and oral examinations and HPV vaccination in young women irrespective of their sexual practices.

  • Examining the Efficacy of 38% Silver Diamine Fluoride in Halting Active Dental Caries Lesions Among Children: A Descriptive Study
    on 23 April 2024

    CONCLUSION: This study demonstrates that 38% SDF is highly effective in halting active dental caries lesions in children.

  • Efficacy of Glass Ionomer Cement as Pit and Fissure Sealant in Permanent First Molars
    on 10 April 2024

    Background/Objectives Pit and fissure caries constitute a predominant portion, approximately 90% in permanent posterior teeth and 44% in primary teeth among children and adolescents. Among various preventive modalities, pit and fissure sealants play a pivotal role in safeguarding these vulnerable areas. Categorized by materials such as glass ionomer, composites, and polyacid-modified glass ionomers, these sealants offer effective protection. This study aims to evaluate the efficacy of glass...

  • Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes
    on 5 April 2024

    Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in most organisms. DSBs initiate recombination-mediated linking of homologous chromosomes, which enables correct chromosome segregation in meiosis. DSBs are generated on chromosome axes by heterooligomeric focal clusters of DSB-factors. Whereas DNA-driven protein condensation is thought to assemble the DSB-machinery, its targeting to chromosome axes is poorly understood. We uncover in mice that efficient...

  • Does the Relationship between Age and Brain Structure Differ in Youth with Conduct Disorder?
    on 1 April 2024

    Conduct disorder (CD) is characterised by persistent antisocial and aggressive behaviour and typically emerges in childhood or adolescence. Although several authors have proposed that CD is a neurodevelopmental disorder, very little evidence is available about brain development in this condition. Structural brain alterations have been observed in CD, and some indirect evidence for delayed brain maturation has been reported. However, no detailed analysis of age-related changes in brain structure...

  • Safety of Clopidogrel vs. Ticagrelor in Dual Antiplatelet Therapy Regimens for High-Bleeding Risk Acute Coronary Syndrome Patients: A Comprehensive Meta-analysis of Adverse Outcomes
    on 1 April 2024

    CONCLUSION: Both drugs are generally safe for treating ACS patients with HBR at baseline, although a higher risk of MI was observed with the use of clopidogrel. Nevertheless, drug choice should factor in regional variations, patient-specific characteristics, cost, accessibility, and potential drug interactions.

  • Application of machine learning for identification of heterotic groups in sunflower through combined approach of phenotyping, genotyping and protein profiling
    on 28 March 2024

    Application of machine learning in plant breeding is a recent concept, that has to be optimized for precise utilization in the breeding program of high yielding crop plants. Identification and efficient utilization of heterotic grouping pattern aided with machine learning approaches is of utmost importance in hybrid cultivar breeding as it can save time and resources required to breed a new plant hybrid/variety. In the present study, 109 genotypes of sunflower were investigated at morphological,...

  • In-tube solid phase extraction with graphitic-based polyurethane sponge as a superhydrophobic sorbent and determination of drug residues in foodstuffs using high-performance liquid chromatography
    on 24 March 2024

    Veterinary drugs used in animal husbandry raise public health concerns due to their residues in the bodies of animals. This study employs a simple and quick sample preparation technique, in-tube solid phase extraction, to extract drug residues from foodstuffs, including eggs, honey, and water. This technique utilizes the synergy of graphitic-based materials and polyurethane sponges (PU) combined through dip coating method to make reusable sorbents for extracting drugs, including amoxicillin,...

  • Comprehensive Analysis of Oral Squamous Cell Carcinomas: Clinical, Epidemiological, and Histopathological Insights With a Focus on Prognostic Factors and Survival Time
    on 20 March 2024

    CONCLUSION: Histopathologically, moderately differentiated OSCC was the most frequently encountered grade, and surgery emerged as the predominant treatment modality. The majority of patients studied had a survival period of three years or less, emphasizing the need for further exploration of factors influencing prognosis and treatment outcomes in OSCC.

  • Green Organo-Photooxidative Method for the Degradation of Methylene Blue Dye
    on 18 March 2024

    This study used an organophoto-oxidative material to degrade the toxic azo dye, methylene blue (MB), due to its hazardous effects on aquatic life and humans. MB is traditionally degraded using metal-based catalysts, resulting in high costs. Several organic acids were screened for organo-photooxidative applications against various azo dyes, and ascorbic acid (AA), also known as vitamin C, was found to be best for degradation due to its high photooxidative activity. It is an eco-friendly, edible,...

  • Stochastic brain dynamics exhibits differential regional distribution and maturation-related changes
    on 14 March 2024

    Functional magnetic resonance imaging (fMRI) is a powerful non-invasive method for studying brain function by analyzing blood oxygenation level-dependent (BOLD) signals. These signals arise from intricate interplays of deterministic and stochastic biological elements. Quantifying the stochastic part is challenging due to its reliance on assumptions about the deterministic segment. We present a methodological framework to estimate intrinsic stochastic brain dynamics in fMRI data without assuming...

  • Effects of virtual reality versus motor imagery versus routine physical therapy in patients with parkinson's disease: a randomized controlled trial
    on 5 March 2024

    CONCLUSION: The current study found that the combination of VR and RPT proved to be the most effective treatment method for improving balance, motor function, and activities of daily living in patients with Parkinson's disease when compared to MI + RPT or RPT alone.

  • Efficacy of Mineral Trioxide Aggregate (MTA) as a Reparative Material in Iatrogenic Furcal Perforations in Mandibular Molars
    on 1 March 2024

    CONCLUSION: This study concludes that the efficacy of MTA as a reparative material in iatrogenic furcal perforations is remarkable and significant.

  • Role of telerehabilitation in the rehabilitation of children with cerebral palsy during COVID-19: A review
    on 1 March 2024

    Individuals with cerebral palsy (CP) have limited mobility and are unable to actively participate in tasks that are part of their daily living. Thus, continuous therapeutic sessions are required to keep such individuals active and engaged in the environment. Due to the coronavirus disease of 2019 (COVID-19) lockdowns, rehabilitation for children with CP was inhibited which consequently put them at risk of losing their functional gains which were obtained through previous in-person therapies. In...

  • Enabling uncertainty estimation in neural networks through weight perturbation for improved Alzheimer's disease classification
    on 21 February 2024

    CONCLUSION: We believe that being able to estimate the uncertainty of a prediction, along with tools that can modulate the behavior of the network to a degree of confidence that the user is informed about (and comfortable with), can represent a crucial step in the direction of user compliance and easier integration of deep learning tools into everyday tasks currently performed by human operators.

  • Concomitant transthyretin cardiac amyloidosis in patients undergoing TAVR for aortic stenosis: A systemic review and meta-analysis
    on 17 February 2024

    CONCLUSION: The overall pooled TTRCA-AS prevalence was reported to be 13.3% in AS patients who underwent TAVR. Furthermore, transthyretin-associated CA was found to be associated with an increased risk of mortality and hospitalization. Large patient population studies are required to assess the safety and efficacy of TAVR in TTRCA-AS patients, as current research report data from small patient cohorts.

  • COVID-19 Testing Trend: A Retrospective Analysis of the Three Major Pandemic Waves in Punjab, Pakistan
    on 15 February 2024

    CONCLUSION: In this study, there is convincing evidence of COVID-19 under-testing and thus under-reporting. This study also suggests that fear-based interventions may be counterproductive; however, economic factors such as education, employment, and traveling are significant in guiding the behavior for infectious disease prevention and management.

  • Salivary Galectin 3 Levels in Schizophrenia Patients
    on 11 February 2024

    CONCLUSION: Galectin 3 levels are raised in the saliva of schizophrenia patients and these levels are positively correlated with levels of galectin 3 in the serum of schizophrenia patients. Galectin 3 levels in the saliva can be an effective indicator in diagnostic confirmation of clinically suspected schizophrenia patients.

  • Echo state networks for the recognition of type 1 Brugada syndrome from conventional 12-LEAD ECG
    on 9 February 2024

    Artificial Intelligence (AI) applications and Machine Learning (ML) methods have gained much attention in recent years for their ability to automatically detect patterns in data without being explicitly taught rules. Specific features characterise the ECGs of patients with Brugada Syndrome (BrS); however, there is still ambiguity regarding the correct diagnosis of BrS and its differentiation from other pathologies. This work presents an application of Echo State Networks (ESN) in the Recurrent...

  • Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry
    on 30 January 2024

    Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical...

  • Optimized two-stage time-truncated control chart for Weibull distribution
    on 24 January 2024

    In this article, an attribute control chart is proposed when the lifetime of a product follows a Weibull distribution in two-stage sampling, which is based on the number of failures from a truncated life test. The coefficients of the proposed double sampling attribute control chart and the test duration are determined so that the average run length when the process is in control is close to the target value. An overview is reported on how double sampling np control charts work. Tables reporting...

  • Predicting the Length of Stay of Cardiac Patients Based on Pre-Operative Variables-Bayesian Models vs. Machine Learning Models
    on 23 January 2024

    Length of stay (LoS) prediction is deemed important for a medical institution's operational and logistical efficiency. Sound estimates of a patient's stay increase clinical preparedness and reduce aberrations. Various statistical methods and techniques are used to quantify and predict the LoS of a patient based on pre-operative clinical features. This study evaluates and compares the results of Bayesian (simple Bayesian regression and hierarchical Bayesian regression) models and machine learning...

  • Whole-genome analysis and evolutionary characterization of cervical and oral human papillomavirus 16
    on 10 January 2024

    High-throughput genome-wide sequencing has revealed high genomic variability of HPV16 in different geographic regions which is the most predominant genotype in human papillomavirus (HPV)-associated malignancies. Analysis of the HPV16 by whole-genome sequence (WGS) is an advanced method for the identification of mutations in the genome. There is limited information about HPV16 diversity in Pakistan, especially at the genomic level. Till now, WGS for HPV16 has not been previously reported in...

  • A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis
    on 9 January 2024

    Axonal degeneration is a central pathological feature of multiple sclerosis and is closely associated with irreversible clinical disability. Current noninvasive methods to detect axonal damage in vivo are limited in their specificity and clinical applicability, and by the lack of proper validation. We aimed to validate an MRI framework based on multicompartment modeling of the diffusion signal (AxCaliber) in rats in the presence of axonal pathology, achieved through injection of a neurotoxin...

  • Effects of transcranial magnetic stimulation on reactive response inhibition
    on 9 January 2024

    Reactive response inhibition cancels impending actions to enable adaptive behavior in ever-changing environments and has wide neuropsychiatric implications. A canonical paradigm to measure the covert inhibition latency is the stop-signal task (SST). To probe the cortico-subcortical network underlying motor inhibition, transcranial magnetic stimulation (TMS) has been applied over central nodes to modulate SST performance, especially to the right inferior frontal cortex and the presupplementary...

  • Adult Para Testicular Spindle Cell Rhabdomyosarcoma: A Case Report From Pakistan
    on 8 January 2024

    Para testicular or intra-scrotal Rhabdomyosarcomas (RMS) are rare. The spindle cell variant of rhabdomyosarcoma is the least common variant among embryonal subtypes. They are mostly seen in childhood but rarely reported in adults. We present a case of a 56-year-old man who presented with a three-year history of painless left inguinoscrotal swelling, which he initially ignored and misinterpreted as an Inguinal hernia but later sought medical help upon a progressive increase in the size of the...

  • A machine learning approach to assess Sustainable Development Goals food performances: The Italian case
    on 2 January 2024

    In this study, we introduce an innovative application of clustering algorithms to assess and appraise Italy's alignment with respect to the Sustainable Development Goals (SDGs), focusing on those related to climate change and the agrifood market. Specifically, we examined SDG 02: Zero Hunger, SDG 12: Responsible Consumption and Production, and SDG 13: Climate Change, to evaluate Italy's performance in one of its most critical economic sectors. Beyond performance analysis, we administered a...

  • Bench to Bedside Development of [18F]Fluoromethyl-(1,2-2H4)choline ([18F]D4-FCH)
    on 23 December 2023

    Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imaging protocols, we developed a more stable choline radiotracer, [^(18)F]fluoromethyl-[1,2-²H(4)]choline ([^(18)F]D4-FCH). [^(18)F]D4-FCH has improved protection against choline oxidase, the key choline catabolic enzyme, via a ¹H/²D isotope effect,...

  • Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases
    on 23 December 2023

    TWIST1 is a transcription factor that is necessary for healthy neural crest migration, mesoderm development, and gastrulation. It functions as a key regulator of epithelial-to-mesenchymal transition (EMT), a process by which cells lose their polarity and gain the ability to migrate. EMT is often reactivated in cancers, where it is strongly associated with tumor cell invasion and metastasis. Early work on TWIST1 in adult tissues focused on its transcriptional targets and how EMT gave rise to...

  • The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPI-Dynamic Contrast-Enhanced challenge
    on 20 December 2023

    CONCLUSIONS: This study reports results from the OSIPI-DCE challenge and highlights the high inter-software variability within K trans $$ {K}^{\mathrm{trans}} $$ estimation, providing a framework for ongoing benchmarking against the scores presented. Through this challenge, the participating teams were ranked based on the performance of their software tools in the particular setting of this challenge. In a real-world clinical setting, many of these tools may perform differently with...

  • Unlocking the anti-diabetic potential of Gymnema sylvestre, Trigonella foenum-graecum, and their combination thereof: An in-vivo evaluation
    on 18 December 2023

    The current study aimed to explore the anti-diabetic effect of aqueous extracts of Gymnema sylvestre, Trigonella foenum-graecum and mixture of both the plants in alloxan-induced diabetic rabbits. A total of 30 rabbits were grouped into six equal groups as: normal control, diabetic control, diabetic treated with 300 mg/kg body weight (bw) G. sylvestre, diabetic treated with 300 mg/kg bw T. foenum-graecum, diabetic treated with 300 mg/kg bw mixture of both the plants and diabetic treated with 500...

  • Beyond multilayer perceptrons: Investigating complex topologies in neural networks
    on 14 December 2023

    This study delves into the crucial aspect of network topology in artificial neural networks (NNs) and its impact on model performance. Addressing the need to comprehend how network structures influence learning capabilities, the research contrasts traditional multilayer perceptrons (MLPs) with models built on various complex topologies using novel network generation techniques. Drawing insights from synthetic datasets, the study reveals the remarkable accuracy of complex NNs, particularly in...

  • Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes
    on 11 December 2023

    Programmed DNA double-strand break (DSB) formation is a unique meiotic feature that initiates recombination-mediated linking of homologous chromosomes, thereby enabling chromosome number halving in meiosis. DSBs are generated on chromosome axes by heterooligomeric focal clusters of DSB-factors. Whereas DNA-driven protein condensation is thought to assemble the DSB-machinery, its targeting to chromosome axes is poorly understood. We discovered in mice that efficient biogenesis of DSB-machinery...

  • Cohort profile: the Pregnancy Risk Infant Surveillance and Measurement Alliance (PRISMA) - Pakistan
    on 10 December 2023

    PURPOSE: Pakistan has disproportionately high maternal and neonatal morbidity and mortality. There is a lack of detailed, population-representative data to provide evidence for risk factors, morbidities and mortality among pregnant women and their newborns. The Pregnancy Risk, Infant Surveillance and Measurement Alliance (PRISMA) is a multicountry open cohort that aims to collect high-dimensional, standardised data across five South Asian and African countries for estimating risk and developing...

  • The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
    on 7 December 2023

    CONCLUSIONS: The comorbidity burden of MCI relative to non-MCI is age-dependent. A model based on comorbidities alone predicted an MCI diagnosis with reasonable accuracy.

  • Interception of vertically approaching objects: temporal recruitment of the internal model of gravity and contribution of optical information
    on 4 December 2023

    Introduction: Recent views posit that precise control of the interceptive timing can be achieved by combining on-line processing of visual information with predictions based on prior experience. Indeed, for interception of free-falling objects under gravity's effects, experimental evidence shows that time-to-contact predictions can be derived from an internal gravity representation in the vestibular cortex. However, whether the internal gravity model is fully engaged at the target motion outset...

  • Association between e-cigarette use and myocardial infarction: a systematic review and meta-analysis
    on 30 November 2023

    CONCLUSIONS: Dual use is associated with an increased risk of MI than e-cigarette use only. Similarly, dual and solely e-cigarette consumption patterns of nicotine delivery are at a higher risk of MI than non-smokers.

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