PhD Student
bilalnizami1992@gmail.com
Bilal Nizami holds a Doctor of Pharmacy degree from the University of Karachi and later obtained his MSc degree in Nanomedicine through the Erasmus Mundus Joint Master’s Degree program between the Université Paris Cite, Université d’Angers, University of Pavia and the University of Patras.
During his master’s thesis he worked on the development of a novel in vitro Blood Brain Barrier model using human induced pluripotent stem cells in the lab of Prof. Gert Fricker at the University of Heidelberg. In 2022, he started his PhD in Medical-Surgical Biotechnologies and Translational Medicine under Professor Nicola Toschi. Currently, he works on using focused ultrasound to disrupt the blood brain barrier to aid the delivery of therapeutic agents. His research also focuses on non-invasive neuromodulation, involving the study of the neuromodulatory effects of magnetic nanoparticles in vivo in autistic models.
Neuromodulation techniques have emerged as transformative tools for treating several neurological and psychiatric disorders, offering alternatives to traditional pharmacological approaches often hindered by the blood-brain barrier and off-target effects. While conventional modalities like deep brain stimulation, transcranial magnetic stimulation, and optogenetics have shown promise, they each face limitations in invasiveness, spatial resolution, or clinical applicability. In recent years,...
Magnetic nanodiscs (MNDs) represent a transformative class of anisotropic magnetic nanoparticles with intrinsic vortex magnetization, enabling multifunctional applications in biomedical imaging and therapy. Here, we demonstrate their potential as dual-mode magnetic resonance (MR) contrast agents, a unique feature which is enabled by the high longitudinal relaxivity (r (1) ≈ 40 mM^(-1) s^(-1)) at ultralow magnetic fields (<70 µT) in combination with strong transverse relaxivity (r (2) > 150...
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