Nicola Toschi is a Full Professor in Medical Physics at the University of Rome “Tor Vergata” and Research Staff and Faculty at the Athinoula A. Martinos Center for Biomedical Imaging (Harvard Medical School).
He has previously worked as a strategy consultant at McKinsey & Company, as a facilitator for the United Nations convention on Climate Change, with the Italian National Television (RAI) and as a project coordinator with AMREF.
His research is interdisciplinary, with a focus on scientific and technological solutions for the deployment of advanced physical and mathematical techniques in order to extract quantitative information of investigative, diagnostic and prognostic value in a clinical context.
He is a senior member of the IEEE society, an active member of ISMRM and OHBM, a founding member of the Alzheimer’s Precision Medicine Initiative (AMPI) a member of the Technical Committee on Cardiopulmonary Systems.
Although inflammation is known to play a role in knee osteoarthritis (KOA), inflammation-specific imaging is not routinely performed. In this article, we evaluate the role of joint inflammation, measured using [11C]-PBR28, a radioligand for the inflammatory marker 18-kDa translocator protein (TSPO), in KOA. Twenty-one KOA patients and 11 healthy controls (HC) underwent positron emission tomography/magnetic resonance imaging (PET/MRI) knee imaging with the TSPO ligand [11C]-PBR28. Standardized...
Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious sequela of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some clinical features overlapping with Kawasaki disease (KD). Our research group and others have highlighted that the spike protein of SARS-CoV-2 can trigger the activation of human endogenous retroviruses (HERVs), which in turn induces inflammatory and immune reactions, suggesting HERVs as contributing factors in COVID-19 immunopathology. With...
CONCLUSION: Our causal approach allowed us to noninvasively evaluate directional interactions between fMRI BOLD signals from brainstem nuclei and cardiovagal outflow.
Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) have been previously used to explore white matter related to human immunodeficiency virus (HIV) infection. While DTI and DKI suffer from low specificity, the Combined Hindered and Restricted Model of Diffusion (CHARMED) provides additional microstructural specificity. We used these three models to evaluate microstructural differences between 35 HIV-positive patients without neurological impairment and 20 healthy controls who...
There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI...
