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CONCLUSIONS: The effect of MRPI on gait performance, partially mediated by α-FC, highlights a dual pattern in which brainstem structural alterations show an association with gait impairment both directly and indirectly through their relationship with cortical functional disruptions.

CONCLUSIONS: This study provides evidence of widespread functional alterations in the local brain networks of de novo Parkinson's disease (PD) patients, suggesting early reorganization of brain connectivity. The disruption index (k) demonstrated the ability to detect early and subtle changes in functional brain networks in de novo Parkinson patients.

Conduct disorder (CD) is the leading global cause of mental health burden in children and adolescents and has recently been hypothesized to be a neurodevelopmental disorder. Although prior research has identified neuroanatomical differences associated with CD, it remains unclear whether these differences reflect atypical brain development. Here, we investigated the difference between an individual's brain age and chronological age as a proxy for variations in brain maturation. Using a pretrained...

CONCLUSIONS: Premorbid statin treatment is associated with a favorable imaging condition of acute ischemic stroke in terms of ischemic core and ischemic penumbra volume.

Background/Objectives: Parkinson's disease (PD) is characterized by progressive neurodegeneration affecting both motor and non-motor functions. Identifying early alterations in PD patients before the onset of dopaminergic therapy is crucial for understanding disease progression and developing targeted interventions. This study aimed to investigate early changes in the putamen and thalamus in de novo PD patients using diffusion tensor imaging (DTI) compared to healthy controls. Methods:...